The story of Culion and the Culioneros begins in the early 20th century when the American colonial government, which then ruled the Philippines, decided to establish a leper colony in the country. At that time, leprosy, also known as Hansen's disease, was a highly stigmatized and feared illness. The disease causes severe disfigurement and disability, leading to intense social discrimination against those afflicted.

The American colonial administration chose Culion Island for its leper colony due to its remote location, which effectively isolated the patients from the general population, a common practice in managing infectious diseases at the time. The colony was officially opened in 1904 and was initially intended to house Filipino and American leprosy patients.

The history of the Culioneros and the leper colony on Culion Island is a significant chapter in the Philippines' narrative, reflecting themes of isolation, resilience, and the human spirit's capacity to adapt and overcome adversity.